Expression of Gallus Epidermal Growth Factor (gEGF) with Food-Grade Lactococcus lactis Expression System and Its Biological Effects on Broiler Chickens

As a multifunctional polypeptide, epidermal growth factor (EGF) increases performance or enhances resistance to diseases in commercial broilers under adverse conditions. In this study, recombinant Lactococcus lactis was established produce the secretory form of bioactive gEGF. The results vitro testing showed that gEGF promoted proliferation chicken embryo fibroblast cells. A total 63 5-day-old broiler chickens were evenly divided into three groups and treated with either M17 medium (the control group), supernatant LL-pNZ8149 fermentation product P-LL LL-pNZ8149-gEGF group). two weeks, many measurements growth, immunity intestines significantly higher group than those groups. Our study could be expressed expression system potential enhance performance, immune function, intestinal development chickens.